Nov

20

When I was a medical reviewer at the FDA in the 1980s, a completely unexpected side effect occurred in the clinical testing of a new formulation of human growth hormone (HGH) synthesized in bacteria.

During the initial clinical studies on healthy volunteers (who happened to be senior executives of the drug company), the drug caused extreme pain at the injection site, fever and abnormalities in blood chemistry that indicated inflammation. The problem resulted not from any anomaly in the growth hormone molecule itself but from a low-level contaminant that, when injected into human subjects, stimulated white blood cells to release a substance that caused the signs and symptoms. Because of the indirect mechanism of its toxicity and its specificity for human cells, the contaminant had been undetectable in both the standard, sophisticated screening tests that are supposed to assure a drug’s purity and quality, and in studies in animals. Thus, the problem only appeared when the drug was injected into humans.

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Jun

24

While anti-aging creams, some with HGH, are so glamorised that only the fairest of celebrities are used to advertise them, the long-term effects are far from beautiful.

Some products may contain HGH or ingredients that stimulate the body to produce its own HGH. Ironically, the hormones don’t slow the aging process, they just hide the symptoms.

Animal studies have shown that animals that produce more growth hormone in old age have a shorter life span. Studies have also shown that HGH causes carpal tunnel syndrome and diabetes. And it has not been adequately tested.

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Jun

3

 One recent study sheds some light on what happens to hgh levels during starvation:

 

Washington, June 27 (ANI): Scientists at the University of Texas Southwestern Medical Center have discovered that chronically high levels of a liver produced starvation hormone, known as FGF21, significantly stop the growth of mice.

Writing about their findings in the journal Cell Metabolism, the researchers said that the hormone does so by causing the mice to become resistant to growth hormone (hgh).

 

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Apr

9

NEW YORK (Reuters Health) - Ten years of growth hormone treatment improves muscle strength in adults who have a deficiency of the hormone. The first five years of treatment restores muscle strength, and the second five years and thereafter slow age-related loss of strength, Swedish investigators say.

Adults with growth hormone deficiency tend to have excess body fat and reduced muscle strength, but little is known about the effect of prolonged growth hormone therapy on muscle strength.

Dr. Galina Gotherstrom and colleagues at Goteborg University evaluated the effects of 10 years of treatment on muscle strength and neuromuscular function in 109 subjects, average age 50 years, with adult-onset growth hormone deficiency.

“Growth hormone replacement induced a sustained increase in lean mass and isometric knee flexor strength” during the first five years, the researchers report in the Journal of Clinical Endocrinology and Metabolism. In addition, there were increases in upper leg and handgrip strength during the first five years of the study.

Over the next five years, muscle strength decreased, returning to initial levels or even lower. However, once age and gender were taken into consideration, “there were sustained and… even progressive increases in the measures of muscle strength” through seven years of follow-up, Gotherstrom and colleagues found.

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Apr

7

Dr. Edmund Chein opened a clinic in Mexico years ago, offering his patients human growth hormone (hgh) injections to avoid the FDA’s ban on the use of human growth hormone (hgh) on adult patients that was in effect before 1996.

Regarding this he states, “In one case you are talking growth hormone deficiency in children and in the other case, you are talking growth hormone deficiency in adults.” The FDA accepted his argument, and in 1994 he becamethe first doctor in the United States to openly offer growth hormone replacement.

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Mar

25

Oxford, 25 March 2009 - In the May-June 2009 issue of the prestigious Archives of Gerontology and Geriatrics, an international journal published by Elsevier, Prof. Dr. Imre Zs.-Nagy, of the University of Debrecen Medical and Health Science Center (Hungary), and founder and Editor-in-Chief of the Archives of Gerontology and Geriatrics (http://www.elsevier.com/locate/archger), presents numerous studies documenting a diverse array of anti-aging medical therapeutics that currently exist and are being applied in the clinical setting today, as well as interventions that are in the laboratory stage, to slow, prevent, and perhaps even reverse the degenerative diseases of aging and the degenerative biological processes which lead to premature disease, disability, dependence, and death.

Further, Dr. Zs.-Nagy expresses his opinions on the use of the hGH (human growth hormone) as an anti-aging medical intervention. The Editorial attempts to point out the main clinical results of hGH replacement therapy (hGHRT) in light of the “Membrane Hypothesis of Aging” (MHA), which Dr. Zs.-Nagy submits as offering a solid basis for the interpretation of the observed beneficial effects of hGH.

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Mar

23

March 17, 2009 — Dr. Michael O. Thorner, a clinician and researcher at the University of Virginia Health System, was invited to present the 2009 Dale Medal lecture, given each year by the recipient of the Society for Endocrinology’s highest honor.

Thorner, a leading expert in growth hormone (hgh) regulation and professor of internal medicine at the U.Va. School of Medicine, was scheduled to lecture on his latest anti-frailty research Tuesday at the Society for Endocrinology’s annual meeting in Harrogate, England.
 
According to the society, the Dale Medal honors researchers who have changed the understanding of endocrinology in a fundamental way.
 
In his lecture, “Healthspan: How Far Can It be Extended into Aging?,” Thorner defines healthspan as “the period of life when people enjoy good health.” As a researcher, his ultimate goal is to prolong healthspan so people have sufficient strength and health to live independently in their elder years.

One of Thorner’s primary research interests has been reversing the decline in growth hormone (hgh) levels that occur during aging. According to Thorner, growth hormone levels peak at mid-puberty and decrease progressively thereafter. This decline ultimately reduces muscle mass and contributes to the development of frailty.

In his latest study published Nov. 4 issue of Annals of Internal Medicine, Thorner and his U.Va. colleagues found that an investigational drug, MK-677, restored growth hormone secretion in the elderly to levels typically found in 20- to 30-year-old adults. Taken orally once a day, the drug increased the muscle mass of study participants, who ranged in age from 60 to 81.

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Mar

17

Despite advertisements on campus for discounted coffee and extended library hours, using caffeine to fuel all-night study sessions may actually make it harder to ace those finals.  

Due to her unusual sleep schedule, one student said she sometimes skips class in order to sleep in and drinks coffee when she is extremely tired, she said. 

Krueger said it is true that caffeine helps with mental focus, but warns against it as a substitute for sleep.

“There’s no doubt about it—caffeine helps performance, but it is also the single most addictive substance,” Krueger said.

He said he has seen studies that show caffeine can help a student focus—but only temporarily. Once the body is used to caffeine intake, a tolerance is built and the student would have to consume more caffeine to receive the same affect.

Whether caffeine or sleep aids are used, sleep deprivation is a problem. In America alone, approximately $2 billion is spent each year on sleep-enhancing drugs, Krueger said.

At Krueger’s laboratory at Washington State University, he researches the biochemical regulation of sleep, sleep and infectious diseases and brain organization as it applies to sleep. .

Students are not the same person when they go without sleep, Krueger said.

“A person’s body temperature and hormone level is altered when they are deprived of sleep,” he said. “Fifty percent of growth hormone (hgh) released is done so during the first stage of sleep.”

Growth hormone helps muscle tone and mass, aids in organ development, including brain development, and stimulates the immune system, Krueger said.

Western counselor Anne Marie Theiler said some students who have sleep-related issues visit Western’s Counseling Center.

“Some students have so much on their minds they have difficulty letting go of the planning and worrying when it is time to get to sleep,” Theiler said. “Some students have lifestyle habits that disrupt sleep—they get to bed earlier during the week, but then stay up late and sleep late on the weekends.”

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Mar

10

WASHINGTON (Reuters) - U.S. regulators will allow experimental use of Insmed’s drug Iplex for certain patients with Lou Gehrig’s disease, the Food and Drug Administration said on Tuesday.

The drug is approved for treating a growth hormone deficiency but is not currently marketed because of a court order related to patent infringement, an FDA notice said.

The agency said a number of doctors had requested permission to use the drug for patients with Lou Gehrig’s disease, also known as amyotrophic lateral sclerosis or ALS. Similar drugs have been tested for the fatal neurological disease but failed to show benefit. Some trials suggested patients may fare worse with one of the medicines than a placebo, the FDA said.

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Mar

2

CHARLOTTESVILLE, Va. (Ivanhoe Newswire) — As we age, it’s natural for our bodies to weaken and become frail, but the natural progression can limit physical activities in the elderly. A new drug is being touted as an anti-frailty pill.

 

A new drug called MK-677 has been shown to increase 20 percent of the lost muscle mass that occurs between mid-puberty and age 70 — a significant boost in muscle. “There were changes in body composition that far exceeded what I had expected,” Dr. Thorner said. The drug works by mimicking and stimulating the body’s natural growth hormone (hgh), restoring hormone levels to those found in healthy 20- to 30-year-olds. The hormones help fuel muscle growth, which may help improve activity levels. “I think that it may be able to enable people to remain independent for longer,” Dr. Thorner said. That’s something Gwaltney hopes for himself lasts a long time.

 

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