Dec

19

A person’s muscle weight is influenced by many factors, including hormones. For instance, human growth hormone (HGH) levels decrease with age, and this drop is associated with a decline in muscle mass.

A new study in the “Annals of Internal Medicine” takes a unique look at this aspect of metabolism. Researchers asked if they could curtail the decline in human growth hormone (hgh) and whether doing so would help people improve their muscle weight. For two years, they studied 65 healthy adults (men and women), ages 60 to 81. They divided them into two groups — one took a placebo, and the other took ghrelin mimetic, a substance to stimulate production of growth hormone. Result: Those receiving ghrelin mimetic did, indeed, increase human growth hormone (hgh) and muscle mass.

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Dec

16

A vigorous 60-minute workout on a treadmill affects the release of two key appetite hormones, ghrelin and peptide YY, while 90 minutes of weight lifting affects the level of only ghrelin, according to a new study. 

Taken together, the research shows that aerobic exercise is better at suppressing appetite than non-aerobic exercise and provides a possible explanation for how that happens. Ghrelin was discovered by researchers in Japan only about 10 years ago and was originally identified for its role as a growth hormone (hgh). Only later did its role in stimulating appetite become known. Peptide YY was discovered less than 25 years ago.

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Nov

4

An oral drug that mimics ghrelin, an appetite hormone, reverses the normal age-related decline in human growth hormone (hgh) and fat-free mass in elderly adults, according to an article in the Nov. 4 issue of the Annals of Internal Medicine.

Ralf Nass, M.D., from the University of Virginia in Charlottesville, and colleagues randomly assigned 65 healthy adults (61 to 80 years old) to once daily placebo or 25 mg MK-677, an oral ghrelin mimetic. “Over 12 months, the ghrelin mimetic MK-677 enhanced pulsatile  human growth hormone (hgh) secretion, significantly increased fat-free mass, and was generally well tolerated,” Nass and colleagues conclude.

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