Mar

11

 Nature rewards shorter women with extra long lives, according to a new study.

The study is based on a survey of more than 450 Ashkenazi (Eastern European) Jews aged between 95 and 110. It is the latest in the researchers’ ongoing search for genetic clues to longevity. Findings of the study have been published in the latest issue of the Proceedings of the National Academy of Sciences.  The latest study focussed on genes involved in the action of insulin-like growth factor (IGF-I), a hormone that is regulated by the human growth hormone (HGH). So the Albert Einstein College scientists reasoned that altered signaling in this pathway might also influence human longevity. since plasma levels of IGF-I do not reflect their levels at a younger age, the researchers also looked at two other groups: their children, and a control group of other Ashkenazi counterparts with no history of longevity. Remarkably, the centenarians’ female offspring had IGF-I plasma levels 35 per cent higher than female controls, perhaps a sign that the body was compensating for a glitch in IGF-I signaling by secreting increased amounts of the hormone (HGH). That suspicion was bolstered by two other findings: the daughters of centenarians were 2.5 cm shorter than female controls.

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