Oct

13

 He was born in central New Jersey, but Kevin E. Yarasheski, Ph.D., started moving west when he started college.

First it was to East Stroudsburg University in the Pocono Mountains of Pennsylvania, where he earned an education degree. Then he went farther west to Kent State University in Ohio, where Yarasheski earned both a master’s degree and a doctorate in exercise physiology.

Yarasheski profile
Photo by Robert Boston
Kevin E. Yarasheski, Ph.D. (right), reviews immunoblots in his lab with Scott Richmond, Ph.D., a postdoctoral scholar in the Division of Endocrinology, Metabolism and Lipid Research. “Kevin is a perfect example of the value of involving people with fresh perspectives to address difficult problems, something that makes Washington University such a unique community of scholars,” says Clay Semenkovich, M.D., the Herbert S. Gasser Professor and chief of the Division of Endocrinology, Metabolism and Lipid Research.

He says his decision to pursue science as a career began with an interest in the biochemistry of physical activity. Yarasheski longed to understand what happened inside muscles during exercise, what activity did to the heart, the liver and fat stored in the body. He knew a research fellowship could allow him to explore not just exercise but also the other things that interested him, too.

But as the debate about HGH raged in the scientific and the popular press, Yarasheski had turned his skills toward a different issue. He was learning about biochemical changes in the muscles of AIDS patients. Muscle wasting was one of the major problems that accompanied HIV infection, and he had studied wasting in the elderly during his first days at WUSTL.

“I wanted to understand the molecular reasons why HIV caused wasting,” he explains. “When I first came here, we were looking at aging and asking why we lose muscle, why we become resistant to insulin and why we become obese as we age. HIV infection was just a different model for looking at many of the same questions.”

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Aug

1

Low doses of human growth hormone (hgh) can reverse some of the abnormal fat distribution caused by HIV therapy, lowering the risk of cardiovascular disease, but the treatment may produce an unnecessary risk for those who have early stages of diabetes, researchers said Sunday.

The hormone (hgh) produced good results but would have to be used carefully to avoid inducing diabetes, said Dr. Steven Grinspoon of the Harvard Medical School, lead author of the paper.

He presented the results, which will be published this week in the Journal of the American Medical Assn., at the International AIDS Conference in Mexico City.

About 40% of males and 16% of females who take cocktails of anti-AIDS drugs for their HIV infections develop fat deposits in the stomach, neck and cheeks.

Called visceral fat, it is associated with higher levels of cholesterol and triglycerides and increases the risk of heart attacks and stroke.

Such patients typically have abnormally low levels of growth hormone (hgh) and researchers had hoped that replacing it with genetically engineered human growth hormone — the same drug used to treat below-normal growth rates and that is abused in athletics — might reverse the effects.

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LATimes/HGH

Feb

26

HGH can help ease the effects of  many suffering from disease and injury.

HGH helps people whose bodies are under stress or wasting because of the effects of AIDS (Acquired Immune Deficiency Syndrome), burns, or traumatic injuries. In AIDS, the wasting syndrome is characterized by significant, unintended weight loss. If you have AIDS and have lost a lot of weight, HGH may help you gain weight. If you add a regimen of resistance exercise (weightbearing workouts), you can accumulate more muscle. Another study showed that after a trauma (severe injury), HGH along with adequate daily nutrition helped to enhance metabolism.

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HGH & Aids/Burn Patients

Feb

11

 Sly and many others, from athletes to actors use HGH to enhance their performance and their physique. Take a look at what The Houston Chronicle is reporting:

With the take-no-prisoners bravado of the character he plays in Rambo, the fourth installment in his hugely successful film franchise, Sylvester Stallone, 61, told Time magazine that HGH was behind the super-buff, senior-licious physique he flaunts in the movie while dispatching a reported 236 bad guys to their maker.

Synthetic HGH is used to replace the growth hormone that’s normally produced in the pituitary in amounts that decline with age. It is used to treat children with certain growth disorders and adults with pituitary failure or HIV-related wasting disease.

Although HGH has not been approved for any other uses, physicians report that athletes and bodybuilders, convinced that it builds muscle and boosts performance, are lining up for the stuff in growing numbers — and becoming savvier consumers, too. “These guys will come in and say, ‘I can get it myself. I want you to tell me if it’s bad for me,’ ” says Dr. Stanley Korenman, an endocrinologist at the University of California, Los Angeles’ David Geffen School of Medicine.

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The Chron On HGH

Dec

12

 What are some of the non anti-aging benefits of HGH? Cecilia Capuzzi Simon wrote a special to The Washington Post on HGH. Here is part of her story:

HGH does many things besides promote growth, and many endocrinologists think it has been misnamed. HGH regulates metabolism, converts fat into muscle and affects lipid levels. It is being studied as a treatment for AIDS patients and others with wasting diseases as well as in burn patients and people who have received transplanted organs.

Though levels of HGH drop after growth is done and as one ages, it is necessary to good health. Adults with growth hormone deficiency are likely to have an abnormal fat/muscle ratio and reduced strength, exercise capacity, cold tolerance, bone mineral content and cardiac output. They are at greater risk for cardiac death and psychosocial problems including depression, irritability and low libido.

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Special to Washington Post/HGH
 

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