Nov

4

An oral drug that mimics ghrelin, an appetite hormone, reverses the normal age-related decline in human growth hormone (hgh) and fat-free mass in elderly adults, according to an article in the Nov. 4 issue of the Annals of Internal Medicine.

Ralf Nass, M.D., from the University of Virginia in Charlottesville, and colleagues randomly assigned 65 healthy adults (61 to 80 years old) to once daily placebo or 25 mg MK-677, an oral ghrelin mimetic. “Over 12 months, the ghrelin mimetic MK-677 enhanced pulsatile  human growth hormone (hgh) secretion, significantly increased fat-free mass, and was generally well tolerated,” Nass and colleagues conclude.

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