Jun

19

 HGH may help cancer patients live longer. Take a look:

It won’t actually cure cancer, but a gene therapy has helped dogs with various malignant tumors live longer, better lives. If it works in humans, the therapy might bring similar benefits for people with cancer.

Ruxandra Draghia-Akli and her colleagues at VGX Pharmaceuticals in The Woodlands, Texas, inserted DNA containing the gene for growth hormone releasing hormone (HGH) into the muscles of 43 pet dogs that were undergoing drug therapy for a range of different cancers. HGH boosts production of growth hormone and insulin-like growth factor-1, both of which build muscle.

Three months later, 54 per cent of the dogs showed signs that they were expressing the inserted genes. These dogs survived for an average of 178 days, compared with 97 days for dogs not given gene therapy. Although the dogs on gene therapy did not on average gain more weight than the ones who weren’t, their appetites increased - an indication that their overall quality of life was better. The results were presented at an Endocrine Society Meeting in San Francisco this week.

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